Reports of fexofenadine overdose is rare, and therefore, the results are not well established. There were no deaths from tests on mice, to 5000 mg / kg, which is 110 times higher than the maximum recommended dose for an adult man. Other research shows no deaths in rats with the same concentration, which is equal to four times the recommended dose in an adult human. Research on humans varies from a single dose of 800 mg, once and twice daily dose of 690 mg for one month, with no clinically significant adverse effects, compared to placebo. For the production of piperidine piece, the two phenyl groups are introduced for the first time in the reaction of Grignard ester, which gives a higher alcohol. The group then alkylated amine with a protected aldehyde, and then recovered from the acid aldehyde deprotection. The remaining portion of the molecule produced by a double by alkylation of iodomethane carbanion nitrile. The nitrile group is hydrolyzed to carboxylic acid. The bromide aryl lithiated after production of organolithium complex, which can be combined with the party giving aldehyde (after workup) fexofenadine.
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